P-gp inhibitors and its clinical significance

P-gp inhibitors

• Amiodarone
• Verapamil
• Itraconazole
• Cyclosporine
• Erythromycin
• Quinidine

Knowledge of P-gp inhibitors is essential to avoid interactions when they are combined with P-gp substrates. Increase in digoxin levels in CNS and subsequent increase in CNS side effects is well documented when used in combination with a P-gp inhibitor.

Pgp substrates:

• Protease inhibitors
• Digoxin
• Colchicine
• Fexofenadine
• Cyclosporine