Showing posts with label Short notes. Show all posts
Showing posts with label Short notes. Show all posts

Friday, July 26, 2019

Short notes: Alcohol withdrawal syndrome


Alcohol withdrawal syndrome 

Pathogenesis: 
Sudden decrease or abrupt stoppage of alcohol in a dependent individual 

Symptoms: 
Anxiety, tremors, palpitations vomiting. 
May progress to severe symptoms including hallucinations, delirium tremens and seizures

Treatment: 
Sedative hypnotics are the mainstay of treatment 
Benzodiazepines like chlordiazepoxide or diazepam 
In non-responders, propofol or barbiturates can be added 

Short notes: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS and TEN)

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS and TEN)
Blisters and mucosal/epidermal detachment due to full-thickness epidermal necrosis  
No significant dermal inflammation

Total body surface area of blistering and eventual detachment determines severity and nomenclature 
<10%: Stevens-Johnson syndrome
10–30%: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) overlap 
>30%: Toxic Epidermal Necrolysis 

Common drugs causing SJS/TEN
BANS Lame COP
Beta lactams
Allopurinol 
Nevirapine/ NSAIDS (oxicam)
Sulfonamides
Lamotrigine
Carbamazepine
Oxcarbazepine
Phenytoin