Short notes: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS and TEN)

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS and TEN)

Blisters and mucosal/epidermal detachment due to full-thickness epidermal necrosis  

No significant dermal inflammation

Total body surface area of blistering and eventual detachment determines severity and nomenclature 

<10%: Stevens-Johnson syndrome

10–30%: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) overlap 

>30%: Toxic Epidermal Necrolysis 

Common drugs causing SJS/TEN

BANS Lame COP

Beta lactams

Allopurinol 

Nevirapine/ NSAIDS (oxicam)

Sulfonamides

Lamotrigine

Carbamazepine

Oxcarbazepine

Phenytoin