Rifampin: mycobacterial and non-mycobacterial indications

Mycobacterium infections:

• Tuberculosis
• Leprosy
• MAC infections 
• M. kansasii, M. marinum, M. ulcerans, M. malmoense, M. haemophilum: first line 
• M. fortuitum complex: alternate 

Note: Not indicated for Mycobacterium abscessus 
Mycobacterium abscessus inactivates rifampin via an ADP-ribosyltransferase and monooxygenase..
Thus, the bacteria is innately resistant to all rifamycins including rifampin.


Non mycobacterium infections:

• Brucellosis: in combination with doxycycline
• Prophylaxis for Meningococcal meningitis and for carrier state
• Haemophilus influenzae type B infection prophylaxis 
• Staphylococcal endocarditis or osteomyelitis (selected cases)