Drugs for Chronic Heart Failure (CHF) classification

1) To improve congestive manifestations and cardiac performance:

a) Inotropic drugs

Digoxin

Dopamine

Dobutamine

Amrinone

Milrinone

b) Diuretics

Furosemide

Thiazides

c) Vasodilators

i) Venodilators(reduce pre-load)

Isosorbide dinitrate

Glyceryl Trinitrate

ii) Arteriolar Dilators (reduce after-load)

Hydralazine

Minoxidil

Nifedipine

Nicorandil

ii) Mixed dilators

Nitroprusside

ACE Inhibitors

Losartan

Prazosin

Phentolamine

d) β adrenergic blocker

Metoprolol

Bisoprolol

Carvedilol

2) To arrest/reverse the disease process and reduce mortality

a) For reduction of neurohumoral activation

ACE Inhibitors

AT1 Antagonists

β-Blockers

b) Aldosterone antagonist

Spironolactone

Newer drugs

1) Neprilysin inhibitor

Sacubitril

2) Vasopeptidase inhibitors

Omapatrilat

Sampratilat

3) Recombinant BNP

Nesiritide

4) Peripheral dopamine agonist

Ibopamine

5) Phosphodiesterase -3 inhibitor

Vesnarinone